Things you should know - Coating process

Things you should know - Coating process

The tablets (from Latin tabuletta) are single-dose solid dosage forms which under pressure of powder or granules on tablet presses are manufactured. The forms of the tablets are different. Especially when taking oral tablets is the biconvex shape (round, up and down curved). A share of almost 50% of all forms of drug tablets makes a special position. In the pharmacopeoia (European Pharmacopoeia (PhEur)), the tablets called Compressio.
This name however was successful in pharmaceutical technology, nor on other medical areas.
Very many active ingredients can be embossed ë patients.
What direct, what most of the middle stage of the grains without any further processing of the powder or powder mixture (the direct tableting) means. In most cases, the extra aid materials required in addition to the actual active substance. The direct tableting is that the powder or the pre-treatment of powder mixtures more prints with or without the addition of AIDS without. It seems so easy and cheap. The downside is that only a few substances have the characteristics necessary to tableting, in particular the fluidity of the stacks and the band forces between the particles to lead. Coarse may be crystalline powder with cubic Crystal best be processed. A particle size of 0. 5 to 1 mm is ideal.
The powder would be dry, so has a residual moisture content of 10% and in printed spaces, which is a maximum relative humidity of 50%.
The addition of help will be necessary for the properties in the powder mixture Heufeld improve and changed the properties of all d ended tablet ë. Improve the flow properties of Haufwerkes: the stearate of Hochdisperses has a high specific surface and can customize up to 40% water, without losing its fluidity.
Another example: talk powderYou benefiting sustainable tablets (= improvement of particle adhesion) and the further disintegration of tablets in the gastro intestinal tract prints to improve: the cellulose, microcrystalline cellulose or cellulose mainly micro-fine, resulted in bruchfesten tablets, but aggravated the flow properties.
By their ability to source, powdered cellulose requires a short decay time.
More binders are the cellulose derivatives of HPMC and HPC, as well as Polyvinylpyrrolidone (PVP-Kollidone). These are very efficient ë nt nat Binder. The dry absorb (granulation without water) in turn includes the variants of HPC, as well as Copovidone. The Group of the explosive devices or decay-promoting resources is brands especially cross-begesturde automatically along certain PvP (Kollidon cl). coated tablets are a core and a smooth, seamless layer. The core is usually a tablet or a grain and from Tablet.
The applied layer is either of the sugar (= classic sugar pill) or by designers of other film (= film coated tablets). The layer is usually colored and can, where appropriate, or other substances, to change the properties of the finished dosage form in the way you want (smell, taste,). ) Coating process is the packaging of a core with layers of sugar. Today more and more other coating materials are used. The layer is only a single thin film and talks about film coated tablets. This is the classical coating method, i. the layer of seeds with sugar solutions.
The high production costs, the difficulties, to the the process (automate) and long time of up to one week per line to standardize can withdraw his increasingly this procedure in favour of the film-coated tablet. In the cold dragieren the sugar solution at normal room temperature is applied, the heated sugar syrup dragieren used in the hot (hot dragieren) (CA.). 50-60 . The operation takes place in the layer dampfkesseln, in which the cores are placed by rotation of the drum in the roles. The layer of fluid is added and progressively includes the cores. At the same time be dried carefully (hot air or IR emitter).
The process is repeated until one has enough strong and durable layer around the core. This may require up to 50 coating companies. The cores experience this weight and volume increases. The difference with the Dragierung is that the core with a single, continuous is coated, colored layer special painting materials. Neither the volume changes still form the core of this. The engraving remain visible.
Although this layer is very thin, she should receive all main advantages of the properties that relate to the reasons for the shift.
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